Exercise Intolerance in Rats With Hypertensive Heart Disease Is Associated With Impaired Diastolic Relaxation
نویسندگان
چکیده
منابع مشابه
Exercise intolerance in rats with hypertensive heart disease is associated with impaired diastolic relaxation.
A decrease in functional capacity is one of the most important clinical manifestations of hypertensive heart disease, but its cause is poorly understood. Our purpose was to evaluate potential causes of hypertension-induced exercise intolerance, focusing on identifying the type(s) of cardiac dysfunction associated with the first signs of exercise intolerance during the course of hypertensive hea...
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BACKGROUND Hypertension is an important clinical problem and is often accompanied by left ventricular (LV) hypertrophy and dysfunction. Whether the myocardial high-energy phosphate (HEP) metabolism is altered in human hypertensive heart disease and whether this is associated with LV dysfunction is not known. METHODS AND RESULTS Eleven patients with hypertension and 13 age-matched healthy subj...
متن کاملDiastolic heart failure, diastolic left ventricular dysfunction and exercise intolerance.
The phenomenon of “diastolic heart failure” is rightly receiving greater attention (1–4); community-based studies such as those in Framingham (5) and Olmsted County (6) show that up to 50% of older persons with heart failure do not have impaired left ventricular (LV) systolic function to account for this, and that the condition is usually associated with LV hypertrophy and is preceded by elevat...
متن کاملExercise Tolerance and the Post Exercise Diastolic Filling Pattern in Patients With the Resting Impaired Relaxation
BACKGROUND In patients with normal LV systolic function, cardiac output increases with exercise mediated by increased stroke volume early in exercise and an increase in heart rate later in exercise. Despite normal LV systolic function, patients who display an impaired relaxation pattern may have a reduced exercise tolerance. We hypothesized that the resting impaired relaxation pattern that pers...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2001
ISSN: 0194-911X,1524-4563
DOI: 10.1161/01.hyp.37.2.204